Indikasi hytrin 1mg
The plasma levels peak about one hour after dosing, and then decline with a half-life of approximately 12 hours. In a study that evaluated the effect of age on Terazosin pharmacokinetics, the mean plasma half-lives were After oral administration the plasma clearance was decreased by The remainder is eliminated as metabolites.
The disposition of the compound in animals is qualitatively similar to that in man. Indications and Usage for Terazosin Terazosin capsules are indicated for the treatment of symptomatic benign prostatic hyperplasia BPH. The long-term effects of Terazosin capsules on the incidence of surgery, acute urinary obstruction or other complications of BPH are yet to be determined.
Terazosin capsules are also indicated for the treatment of hypertension. It can be used alone or in combination with other antihypertensive agents such as diuretics or beta-adrenergic blocking agents. Contraindications Terazosin capsules are contraindicated in patients known to be hypersensitive to Terazosin hydrochloride.
Warnings Syncope and "First-Dose" Effect Terazosin capsules, like other alpha-adrenergic blocking agents, can cause marked lowering of blood pressure, especially postural hypotension, and syncope in association with the first dose or first few days of therapy. A similar effect can be anticipated if therapy is interrupted for several days and then restarted.
Syncope has also been reported with other alpha-adrenergic blocking agents in association with rapid dosage increases or the introduction of another antihypertensive drug. Syncope is believed to be due to an excessive postural hypotensive effect, although occasionally the syncopal episode has been preceded by a bout of severe supraventricular tachycardia with heart rates of to beats per minute.
Additionally, the possibility of the contribution of hemodilution to the symptoms of postural hypotension should be considered. To decrease the likelihood of syncope or excessive hypotension, treatment should always be initiated with a 1 mg dose of Terazosin, given at bedtime.
The 2 mg, 5 mg and 10 mg capsules are not indicated as initial therapy. Dosage should then be increased slowly, according to recommendations in the Dosage and Administration section and additional antihypertensive agents should be added with caution.
The patient should be cautioned to avoid situations, such as driving or hazardous tasks, where injury could result should syncope occur during initiation of therapy. In early investigational studies, where increasing single doses up to 7. Syncopal episodes occurred in 3 of the 14 subjects given Terazosin at doses of 2.
These adverse effects all occurred within 90 minutes of dosing. Syncope was not necessarily associated only with the first dose. If syncope occurs, the patient should be placed in a recumbent position and treated supportively as necessary. There is evidence that the orthostatic effect of Terazosin is greater, even in chronic use, shortly after dosing.
The risk of the events is greatest during the initial seven days of treatment, but continues at all time intervals. Two or three dozen cases have been reported. These two diseases frequently co-exist. Therefore, patients thought to have BPH should be examined prior to starting Terazosin hydrochloride capsules therapy to rule out the presence of carcinoma of the prostate.
This variant of small pupil syndrome is characterized by the combination of a flaccid iris that billows in response to intraoperative irrigation currents, progressive intraoperative miosis despite preoperative dilation with standard mydriatic drugs, and potential prolapse of the iris toward the phacoemulsification incisions.
The patient's ophthalmologist should be prepared for possible modifications to their surgical technique, such as the utilization of iris hooks, iris dilator rings, or viscoelastic substances.
There does not appear to be a benefit of stopping alpha-1 blocker therapy prior to cataract surgery. Patients with occupations in which such events represent potential problems should be treated with particular caution. Information for Patients see Patient Package Insert Patients should be made aware of the possibility of syncopal and orthostatic symptoms, especially at the initiation of therapy, and to avoid driving or hazardous tasks for 12 hours after the first dose, after a dosage increase and after interruption of therapy when treatment is resumed.
They should be cautioned to avoid situations where injury could result should syncope occur during initiation of Terazosin therapy. They should also be advised of the need to sit or lie down when symptoms of lowered blood pressure occur, although these symptoms are not always orthostatic, and to be careful when rising from a sitting or lying position. If dizziness, light-headedness, or palpitations are bothersome they should be reported to the physician, so that dose adjustment can be considered.
Patients should also be told that drowsiness or somnolence can occur with Terazosin, requiring caution in people who must drive or operate heavy machinery. Patients should be advised about the possibility of priapism as a result of treatment with Terazosin capsules and other similar medications. Patients should know that this reaction to Terazosin capsules is extremely rare, but that if it is not brought to immediate medical attention, it can lead to permanent erectile dysfunction impotence.
Laboratory Tests Small but statistically significant decreases in hematocrit, hemoglobin, white blood cells, total protein and albumin were observed in controlled clinical trials. These laboratory findings suggested the possibility of hemodilution. Treatment with Terazosin for up to 24 months had no significant effect on prostate specific antigen PSA levels.
Drug Interactions In controlled trials, Terazosin has been added to diuretics, and several beta-adrenergic blockers; no unexpected interactions were observed. These effects are more likely to occur after the first few doses or if your dose has increased, but can occur at any time while you are taking the medicine.
It can also occur if you stop taking the medicine and then restart treatment. Hytrin may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment.
Be sure to take your medicine even if you may not feel "normal. Do NOT take more than the recommended dose without checking with your doctor.
Hytrin may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens. Tell your doctor or dentist that you take Hytrin before you receive any medical or dental care, emergency care, or surgery including eye surgery.
Lab tests, including blood pressure, may be performed while you use Hytrin. These tests may be used to monitor your condition or check for side effects.
Be sure to keep all doctor and lab appointments. Hytrin should not be used in children; safety and effectiveness in children have not been confirmed. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Hytrin while you are pregnant.
It is not known if Hytrin is found in breast milk. If you are or will be breast-feeding while you use Hytrin, check with your doctor. Discuss any possible risks to your baby. Check with your doctor if any of these most common side effects persist or become bothersome: Dizziness; drowsiness; lightheadedness; nasal congestion; nausea; weakness.
HYTRIN 1MG TAB
There is evidence that the orthostatic effect of Terazosin is greater, even in chronic use, shortly after dosing. Syncope has also been reported with other alpha-adrenergic blocking 1mg in association with rapid dosage increases or hytrin introduction of hytrin antihypertensive drug. Be sure to take your medicine even if you may not feel "normal, indikasi hytrin 1mg. Blood pressure responses were measured at indikasi end of the dosing indikasi usually 24 hours and effects were shown to persist throughout the interval, indikasi hytrin 1mg, hytrin the usual supine responses 5 to 10 1mg systolic hytrin 3. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue ; blurred vision or other vision changes; chest pain; decreased sexual desire or ability; fainting; fast, slow, or irregular heartbeat;painful, prolonged erection; severe or prolonged dizziness or headache; shortness indikasi breath; swelling of the ankles, indikasi hytrin 1mg, feet, or hands. After oral administration the plasma clearance was decreased by The disposition of the compound in animals 1mg qualitatively similar to that in man. Administration of capsules immediately after meals had a minimal effect on the extent of absorption. Discuss any valium tabletas 10mg risks to 1mg baby. They should also be advised of the need to sit or lie down when symptoms of lowered blood pressure occur, although these symptoms are not always orthostatic, and indikasi be careful when rising from a sitting or lying position.
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