Pentasa 500mg tablet

What are the side effects of Pentasa? The most commonly reported side effects when taking Pentasa tablets mg include: When should Pentasa not be used? You should not use Pentasa tablets mg if you: You should take your Pentasa tablets mg with a glass of water or dispersed in 50 ml cold water, with or without food.

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All medical content is supplied by a third party company who is independent from this web site. Note that not all products are shipped by our contracted Canadian pharmacy. No evidence of mutagenicity was observed in an in vitro Ames test and in an in vivo mouse micronucleus test. Semen abnormalities and infertility in men, which have been reported in association with sulfasalazine, have not been seen with PENTASA capsules during controlled clinical trials. There are, however, no adequate and well-controlled studies in pregnant women.

Because animal reproduction studies are not always predictive of human response, PENTASA should be used during pregnancy only if clearly needed. Mesalazine is metabolised both pre-systemically by the intestinal mucosa and systemically in the liver to N-acetyl mesalazine acetyl mesalazine. The acetylation seems to be independent of the acetylator phenotype of the patient. Some acetylation also occurs through the action of colonic bacteria.

Acetyl mesalazine is thought to be clinically as well as toxicologically inactive, although this remains to be confirmed. Mesalazine is detectable in plasma approximately 15 minutes following administration.

Maximum plasma concentrations are seen 1 - 4 hours post-dose. After a gradual decrease, mesalazine will no longer be detectable 12 hours post-dose. The plasma concentration curve for acetyl mesalazine follows the same pattern, but the concentrations are generally higher and the elimination is slower. Store the enema at room temperature, away from heat, moisture, and direct light. Before Using TOP In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do.

This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies TOP Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies , such as to foods, dyes, preservatives, or animals.

For non-prescription products, read the label or package ingredients carefully. Pediatric TOP Appropriate studies have not been performed on the relationship of age to the effects of mesalamine in the pediatric population. Safety and efficacy have not been established. Geriatric TOP Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of mesalamine in the elderly.

However, elderly patients are more likely to have blood problems eg, neutropenia , pancytopenia and age-related kidney disease , which may require caution and an adjustment in the dose for patients receiving mesalamine. Breast Feeding TOP There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions TOP Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary.

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