Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Alcohol may also affect your blood levels of this drug. Tell your doctor you are using phenytoin prior to surgery or any procedure that makes you unable to take it by mouth.
If you have diabetes , this drug may increase your blood sugar levels. Check your blood or urine glucose level frequently, as directed by your doctor. Promptly report any abnormal results as directed. Your medicine, exercise plan, or diet may need to be adjusted. Vitamin D supplements may be necessary to prevent weakening of the bones osteomalacia. Discuss this with your doctor. During pregnancy , this medication should be used only when clearly needed.
It may harm an unborn baby. However, since untreated seizures are a serious condition that can harm both a pregnant woman and her unborn baby, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately talk to your doctor about the benefits and risks of using this medication during pregnancy. Since birth control pills , patches, implants, and injections may not work if taken with this medication see also Drug Interactions section , discuss reliable forms of birth control with your doctor.
Phenytoin passes into breast milk. Consult your doctor before breast-feeding. Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them.
Effects On Vitamin D And Bone The chronic use of phenytoin in patients with epilepsy has been associated with decreased bone mineral density osteopenia , osteoporosis , and osteomalacia and bone fractures.
Phenytoin induces hepatic metabolizing enzymes. This may enhance the metabolism of vitamin D and decrease vitamin D levels, which may lead to vitamin D deficiency , hypocalcemia , and hypophosphatemia. Consideration should be given to screening with bone-related laboratory and radiological tests as appropriate and initiating treatment plans according to established guidelines.
Effects Of Alcohol Use On Phenytoin Serum Levels Acute alcoholic intake may increase phenytoin serum levels while chronic alcohol use may decrease serum levels. Exacerbation Of Porphyria In view of isolated reports associating phenytoin with exacerbation of porphyria , caution should be exercised in using this medication in patients suffering from this disease. Usage In Pregnancy Clinical Risks to Mother An increase in seizure frequency may occur during pregnancy because of altered phenytoin pharmacokinetics.
However, postpartum restoration of the original dosage will probably be indicated. Risks to the Fetus If this drug is used during pregnancy, or if the patient becomes pregnant while taking the drug, the patient should be apprised of the potential harm to the fetus. Prenatal exposure to phenytoin may increase the risks for congenital malformations and other adverse developmental outcomes. Increased frequencies of major malformations such as orofacial clefts and cardiac defects , minor anomalies dysmorphic facial features, nail and digit hypoplasia , growth abnormalities including microcephaly , and mental deficiency have been reported among children born to epileptic women who took phenytoin alone or in combination with other antiepileptic drugs during pregnancy.
There have also been several reported cases of malignancies, including neuroblastoma , in children whose mothers received phenytoin during pregnancy. However, the relative contributions of antiepileptic drugs and other factors associated with epilepsy to this increased risk are uncertain and in most cases it has not been possible to attribute specific developmental abnormalities to particular antiepileptic drugs. Patients should consult with their physicians to weigh the risks and benefits of phenytoin during pregnancy.
Postpartum Period A potentially life-threatening bleeding disorder related to decreased levels of vitamin K dependent clotting factors may occur in newborns exposed to phenytoin in utero. This drug-induced condition can be prevented with vitamin K administration to the mother before delivery and to the neonate after birth.
Nonclinical Administration of phenytoin to pregnant animals resulted in teratogenicity increased incidences of fetal malformations and other developmental toxicity including embryofetal death, growth impairment, and behavioral abnormalities in multiple animal species at clinically relevant doses. Slow metabolism may be due to limited enzyme availability and lack of induction; it appears to be genetically determined.
Promptly report any abnormal results as directed. Your medicine, exercise plan , or diet may need to be adjusted. Vitamin D supplements may be necessary to prevent weakening of the bones osteomalacia. Discuss this with your doctor. During pregnancy , this medication should be used only when clearly needed.
It may harm an unborn baby. However, since untreated seizures are a serious condition that can harm both a pregnant woman and her unborn baby, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately talk to your doctor about the benefits and risks of using this medication during pregnancy.
Since birth control pills , patches, implants, and injections may not work if taken with this medication see also Drug Interactions section , discuss reliable forms of birth control with your doctor. Phenytoin passes into breast milk. Consult your doctor before breast -feeding. Interactions See also How to Use section. Drug interactions may change how your medications work or increase your risk for serious side effects.
This document does not contain all possible drug interactions. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug include: Other medications can affect the removal of phenytoin from your body, which may affect how phenytoin works. Examples include amiodarone , azole antifungals such as itraconazole , macrolide antibiotics such as erythromycin , estrogens , isoniazid , rifamycins such as rifabutin , St.
John's wort, other anti- seizure medicines such as valproic acid , among others. Phenytoin can speed up the removal of other medications from your body, which may affect how they work. Examples of affected drugs include atazanavir , some drugs to treat cancer such as imatinib , irinotecan , cobicistat, corticosteroids such as prednisone , felodipine , quetiapine , quinidine , suvorexant , theophylline, vitamin D , among others.
This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use additional reliable birth control methods while using this medication. Some products that may interact with this drug include: Other medications can affect the removal of phenytoin from your body, which may affect how phenytoin works.
Examples include amiodarone, azole antifungals such as itraconazole , macrolide antibiotics such as erythromycin , estrogens, isoniazid, rifamycins such as rifabutin , St. John's wort, other anti-seizure medicines such as valproic acid , among others. Phenytoin can speed up the removal of other medications from your body, which may affect how they work. Examples of affected drugs include atazanavir, some drugs to treat cancer such as imatinib, irinotecan , cobicistat, corticosteroids such as prednisone , felodipine, quetiapine, quinidine, suvorexant, theophylline, vitamin D, among others.
This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use additional reliable birth control methods while using this medication. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well.
This product can affect the results of certain lab tests. Make sure laboratory personnel and your doctors know you use this drug. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call Otherwise, call a poison control center right away. US residents can call their local poison control center at Canada residents can call a provincial poison control center.
Symptoms of overdose may include: If you miss your once daily dose, use it as soon as you remember. However, if you do not remember until the next day, skip the missed dose and resume your usual dosing schedule.
If you take several doses daily and miss a dose, use it as soon as you remember unless it is within 4 hours of the next dose. In that case, skip the missed dose and resume your usual schedule. Check with your doctor if you miss doses for more than 2 days in a row. Do not double the dose to catch up. Do not share this medication with others.
Consult your doctor for more details.
A potentially life-threatening bleeding disorder related to decreased levels of vitamin K-dependent clotting factors may occur in newborns exposed to phenytoin in utero. However, if you phenytoin not remember until the 100mg day, skip the missed dose phenytoin resume your usual dosing schedule. Drug Interactions There are 100mg drugs which may increase or decrease phenytoin levels or which phenytoin may affect. Many people using this medication do not have serious side effects, phenytoin extended cap 100mg. Phenytoin passes into breast milk. Phenytoin is used to control certain types of seizures, phenytoin extended cap 100mg. However, patients should be cautioned not to miss a dose, inadvertently. Immunologic Hypersensitivity syndrome extended may include, but is not limited to, symptoms such as arthralgias, eosinophilia, cap, liver dysfunction, lymphadenopathy, or extendedsystemic lupus erythematosus, periarteritis cap and immunoglobulin abnormalities. Phenytoin is not indicated for ribavirin virazole onde comprar due to hypoglycemic or other metabolic causes.
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