In the management of hypertension the maximum effect of Atacand HCT at any dose is manifested within 4-weeks of starting the drug. Administering more than 32 mg of the drug does not help in lowering your blood pressure further, thus it does not yield better effects. The maximum dose recommended is 32 mg and should not be exceeded. As a online prescription service, we ensure that you get brand or generic Atacand HCT at the lowest price possible.

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All medical content is supplied by a third party company who is independent from this web site. Before using this medication , tell your doctor or pharmacist your medical history, especially of: This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.

Too much sweating , diarrhea , or vomiting may cause you to feel lightheaded. Report prolonged diarrhea or vomiting to your doctor. This product may increase your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs , nonprescription drugs, and herbal products.

Older adults may be more sensitive to the side effects of this drug, especially dizziness , increases in potassium level, and change in the amount of urine kidney problems. This medication is not recommended for use during pregnancy. It may harm an unborn baby. Consult your doctor for more details. See also Warning section.

It is unknown if this drug passes into breast milk. Consult your doctor before breast -feeding. Interactions See also Precautions section. Drug interactions may change how your medications work or increase your risk for serious side effects.

This document does not contain all possible drug interactions. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug include: Candesartan and its inactive metabolite do not accumulate in serum upon repeated once-daily dosing. After tablet ingestion, the peak serum concentration Cmax is reached after 3 to 4 hours.

Food with a high fat content does not affect the bioavailability of candesartan after candesartan cilexetil administration. Hydrochlorothiazide When plasma levels have been followed for at least 24 hours, the plasma half-life has been observed to vary between 5.

Metabolism and Excretion Candesartan Cilexetil Total plasma clearance of candesartan is 0. Biliary excretion contributes to the elimination of candesartan. Hydrochlorothiazide Hydrochlorothiazide is not metabolized but is eliminated rapidly by the kidney. Distribution Candesartan Cilexetil The volume of distribution of candesartan is 0. The protein binding is constant at candesartan plasma concentrations well above the range achieved with recommended doses.

In rats, it has been demonstrated that candesartan crosses the blood-brain barrier poorly, if at all. It has also been demonstrated in rats that candesartan passes across the placental barrier and is distributed in the fetus. Hydrochlorothiazide Hydrochlorothiazide crosses the placental but not the blood-brain barrier and is excreted in breast milk. The pharmacokinetics of candesartan were linear in the elderly, and candesartan and its inactive metabolite did not accumulate in the serum of these subjects upon repeated, once-daily administration.

Gender There is no difference in the pharmacokinetics of candesartan between male and female subjects. Renal Insufficiency In hypertensive patients with renal insufficiency, serum concentrations of candesartan were elevated. The pharmacokinetics of candesartan in hypertensive patients undergoing hemodialysis are similar to those in hypertensive patients with severe renal impairment.

Candesartan cannot be removed by hemodialysis. Thiazide diuretics are eliminated by the kidney, with a terminal half-life of hours. Hepatic Insufficiency The pharmacokinetics of candesartan were compared in patients with mild Child-Pugh A or moderate Child-Pugh B hepatic impairment to matched healthy volunteers following a single dose of 16 mg candesartan cilexetil.

The pharmacokinetics of candesartan in severe hepatic impairment have not been studied. No dose adjustment is recommended for patients with mild hepatic impairment. Monitor patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.

Pharmacodynamics Candesartan Cilexetil Candesartan inhibits the pressor effects of angiotensin II infusion in a dose-dependent manner.

Plasma concentrations of angiotensin I and angiotensin II, and plasma renin activity PRA , increased in a dose-dependent manner after single and repeated administration of candesartan cilexetil to healthy subjects and hypertensive patients. ACE activity was not altered in healthy subjects after repeated candesartan cilexetil administration. The once-daily administration of up to 16 mg of candesartan cilexetil to healthy subjects did not influence plasma aldosterone concentrations, but a decrease in the plasma concentration of aldosterone was observed when 32 mg of candesartan cilexetil was administered to hypertensive patients.

In spite of the effect of candesartan cilexetil on aldosterone secretion, very little effect on serum potassium was observed. In multiple-dose studies with hypertensive patients, there were no clinically significant changes in metabolic function including serum levels of total cholesterol, triglycerides, glucose, or uric acid.

In a week study of patients with non-insulin-dependent type 2 diabetes mellitus and hypertension, there was no change in the level of HbA1c. Hydrochlorothiazide After oral administration of hydrochlorothiazide, diuresis begins within 2 hours, peaks in about 4 hours and lasts about 6 to 12 hours. These 5 trials, of 8 to 12 weeks duration, randomized hypertensive patients.

Doses ranged from 2 to 32 mg candesartan cilexetil and from 6. The placebo corrected trough to peak ratio was evaluated in a study of candesartan cilexetil-hydrochlorothiazide Most of the antihypertensive effect of the combination of candesartan cilexetil and hydrochlorothiazide was seen in 1 to 2 weeks with the full effect observed within 4 weeks. In long-term studies of up to 1 year, the blood pressure lowering effect of the combination was maintained.

The antihypertensive effect was similar regardless of age or gender, and overall response to the combination was similar in black and non-black patients. No appreciable changes in heart rate were observed with combination therapy in controlled trials. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions.

These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including the class to which this drug principally belongs. Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than one drug to achieve blood pressure goals.

Numerous antihypertensive drugs, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be concluded that it is blood pressure reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits.

It can lower your blood pressure and may increase some of the side effects of hydrochlorothiazide and candesartan. Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink.

In some cases, drinking too much liquid can be as unsafe as not drinking enough. Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and candesartan, unless your doctor has told you to. What other drugs will affect hydrochlorothiazide and candesartan Atacand HCT? Tell your doctor about all other medicines you use, especially:

Atacand plus 16 mg / 12.5 mg and/or Equivalents Candesartan And Hydrochlorothiazide 16 mg / 12.5 mg

Use in moderate to severe Hepatic Impairment: Atacand HCT 32—25 contains 32 mg of candesartan cilexetil and 25 mg of hydrochlorothiazide. In rats, 5mg has been demonstrated that candesartan crosses the blood-brain barrier poorly, if at all. What conditions does Atacand treat? This is not a complete list of possible side effects, atacand 12 5mg. More than of these patients were studied for at least six months and more than patients were treated for at least one year. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. Hydrochlorothiazide Hydrochlorothiazide crosses the placental but not the blood-brain barrier and is excreted in breast milk. Potassium Abnormalities Drugs that inhibit the renin-angiotensin system can cause hyperkalemia. In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium salt.

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