A case report published in Therapeutic Advances in Psychopharmacology in suggested that baclofen might be effective for treating marijuana dependence, particularly for those who have used the drug heavily for a long time. The research also showed that baclofen may help reduce withdrawal symptoms as well as the effects of marijuana. A separate study, published in the Journal of Neuroscience in , found that baclofen may also help people with drug addiction avoid possible triggers and prevent relapse.
The drug works by interfering with the brain's early response to drug cues. Overdose If someone has overdosed and has serious symptoms such as passing out or trouble breathing , call Otherwise, call a poison control center right away. US residents can call their local poison control center at Canada residents can call a provincial poison control center. Symptoms of overdose may include: Notes Do not share this medication with others.
This medication has been prescribed for your current condition only. Do not use it later for another condition unless your doctor directs you to do so. A different medication may be necessary in that case.
Missed Dose If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule. Do not double the dose to catch up. Storage Store at room temperature away from light and moisture. So, this preparation is quite effectual and at the same, quite dangerous as many people get easily addicted to it.
You must be very cautious while taking this preparation. The contradictions are the next — hypersensitivity to the preparation or to any excipient of it, gastric ulcer and duodenal ulcer in the acute stage, porphyria.
Flexeril is another muscle relaxant. In severely affected children, the oral dose is so high that side-effects appear, and the treatment loses its benefit. How and when baclofen came to be used in the spinal sac intrathecally remains unclear, but as of [update] , this has become an established method of treating spasticity in many conditions. Intrathecal pumps offer much lower doses of baclofen because they are designed to deliver the medication directly to the spinal fluid rather than going through the digestive and blood system first.
They are often preferred in spasticity patients such as those with spastic diplegia , as very little of the oral dose actually reaches the spinal fluid. Baclofen tablets may also be of some value in patients with spinal cord injuries and other spinal cord diseases. Baclofen tablets are not indicated in the treatment of skeletal muscle spasm resulting from rheumatic disorders. Hallucinations and seizures have occurred on abrupt withdrawal of baclofen.
Therefore, except for serious adverse reactions, the dose should be reduced slowly when the drug is discontinued. Because baclofen is primarily excreted unchanged through the kidneys, it should be given with caution, and it may be necessary to reduce the dosage.
Baclofen has not significantly benefited patients with stroke. These patients have also shown poor tolerability to the drug. Baclofen has been shown to increase the incidence of omphaloceles ventral hernias in fetuses of rats given approximately 13 times the maximum dose recommended for human use, at a dose which caused significant reductions in food intake and weight gain in dams. This abnormality was not seen in mice or rabbits.
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